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However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]

Common neurologic manifestations include paresthesias, weakness, gait abnormalities, and cognitive or behavioral changes

2008 [cited 2020 Apr 29];24(10):294352

Relief Sought: His complaint stated that he was seeking actual and compensatory damages and punitive or exemplary damages